Anyone who used macs before they got popular will have heard of Susan Kare, or will go “duh” when shown her work. From the AIGA medal page:
she created some of the most recognizable icons, typefaces, and graphic elements in personal computing: the command symbol (⌘), the system-failure bomb, the paintbrush, and, of course, “Clarus the Dogcow.”
She drew many of her creations by hand, using the smallest graph paper she could find–a 32×32 grid that so happened to total 1024, one square per pixel. Other iconic creations include the Chicago font. She later spent time at facebook and pinterest, but it’s her work at apple that is so meaningful.